OptiEndocrine Balance

 Why Use OptiEndocrine Balance?

Research suggests OptiEndocrine Balance will:

• Support healthy estrogen balance
• Promote healthy inflammatory markers
• Support healthy endocrine function
• Promote healthy cardiovascular and immune function
• Support balanced moods and well-being

How OptiEndocrine Balance Works?

OptiEndocrine Balance supports gastrointestinal integrity and function, which keeps hormone byproducts from being recycled and burden the liver. 

Converts estrogen metabolites to an inactive form through use of flax lignans and isoflavones.⁴  Promotes healthy balance of estradiol and estrogen precursors by utilizing Calcium D-glucarate.⁵

What is OptiEndocrine Balance?

OptiEndocrine Balance is a comprehensive blend of evidence-based ingredients that support healthy estrogen balance and endocrine function.  This formula has been thoroughly researched and demonstrated to be effective in clinical settings.  

Foundational ingredients in OptiEndocrine Balance include diindolylmethane (DIM), Calcium D-glucarate, flax lignans, resveratrol, and isoflavones, which research has shown act on specific enzymes in the body that mediate a healthy estrogen response.^1,2  Specifically, DIM has been shown to act on certain enzymes that support estrogen balance in the body.^2,3

Shown in clinical settings to help balance healthy estrogen levels through key herbal extracts, bioactive micronutrients, lignans, isoflavones, and antioxidants.  Proper estrogen balance is key for supporting healthy mood, well-being, energy levels, and a multitude of other functions in the body.

OptiEndocrine Balance supports estrogen balance through a precise blend of endocrine-supporting antioxidant compounds, such as resveratrol, EGCG (from green tea), curcumin, and grape seed extract.  These ingredients act as phytoestrogens (plant based) interacting with estrogen receptors supporting human health and longevity, particularly by encouraging healthy cardiovascular and immune function.^{6,7,8,9,10,11}

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

 References:

1. Michnovicz, J. J., Adlercreutz, H., & Bradlow, H. L. (1997). Changes in levels of urinary estrogen metabolites after oral indole-3-carbinol treatment in humans. Journal of the National Cancer Institute, 89(10), 718-723.

2. Chen, I., McDougal, A., Wang, F., & Safe, S. (1998). Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethane. Carcinogenesis, 19(9), 1631-1639.

3. Leong, H., Riby, J. E., Firestone, G. L., & Bjeldanes, L. F. (2004). Potent ligand-independent estrogen receptor activation by 3, 3’-diindolylmethane is mediated by cross talk between the protein kinase A and mitogen-activated protein kinase signaling pathways. Molecular Endocrinology, 18(2), 291-302.

4. Vitale, D. C., Piazza, C., Melilli, B., Drago, F., & Salomone, S. (2013). Isoflavones: estrogenic activity, biological effect and bioavailability. European journal of drug metabolism and pharmacokinetics, 38(1), 15-25.

5. Lampe, J. W., Li, S. S., Potter, J. D., & King, I. B. (2002). Serum β-glucuronidase activity is inversely associated with plant-food intakes in humans. The Journal of nutrition, 132(6), 1341-1344.

6. Gehm, B. D., McAndrews, J. M., Chien, P. Y., & Jameson, J. L. (1997). Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proceedings of the National Academy of Sciences, 94(25), 14138-14143.

7. Goodin, M. G., Fertuck, K. C., Zacharewski, T. R., & Rosengren, R. J. (2002). Estrogen receptor-mediated actions of polyphenolic catechins in vivo and in vitro. Toxicological Sciences, 69(2), 354- 361.

8. Breithofer, A., Graumann, K., Scicchitano, M. S., Karathanasis, S. K., Butt, T. R., & Jungbauer, A. (1998). Regulation of human estrogen receptor by phytoestrogens in yeast and human cells. The Journal of steroid biochemistry and molecular biology, 67(5-6), 421-429.

9. Nagao, T., Hase, T., & Tokimitsu, I. (2007). A green tea extract high in catechins reduces body fat and cardiovascular risks in humans. Obesity, 15(6), 1473-1483.

10. Bradamante, S., Barenghi, L., & Villa, A. (2004). Cardiovascular protective effects of resveratrol. Cardiovascular drug reviews, 22(3), 169-188.

11. Aggarwal, B. B., & Harikumar, K. B. (2009). Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. The international journal of biochemistry & cell biology, 41(1), 40-59.